Linkage disequilibrium—the nonrandom association of alleles at different loci—is a sensitive
indicator of the population genetic forces that structure a genome. Because of the explosive …

Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

Metabolic phenotypes are the products of interactions among a variety of factors—dietary,
other lifestyle/environmental, gut microbial and genetic,,. We use a large-scale exploratory …

The International HapMap Project was designed to create a genome-wide database of
patterns of human genetic variation, with the expectation that these patterns would be useful …

The considerable range of observed phenotypic variation in human populations may reflect,
in part, distinctive processes of natural selection and adaptation to variable environmental …

Because population stratification can cause spurious associations in case-control studies,
understanding the population structure is important. Here, we examined Japanese …

Evolutionary pressures due to variation in climate play an important role in shaping
phenotypic variation among and within species and have been shown to influence variation …

Hair morphology is one of the most differentiated traits among human populations. However,
genetic backgrounds of hair morphological differences among populations have not been …

Major histocompatibility complex (MHC) variation is a key determinant of susceptibility and
resistance to a large number of infectious, autoimmune and other diseases. Identification of …

The genetic basis of the development and variation of adult form of vertebrates is not well
understood. To address this problem, we performed a mutant screen to identify genes …