Previous work on the DNA damage checkpoint in Saccharomyces cerevisiae has shown that
two complexes independently sense DNA lesions: the kinase Mec1-Ddc2 and the PCNA …

The DNA damage checkpoint and the spindle assembly checkpoint (SAC) are two important
regulatory mechanisms that respond to different lesions. The DNA damage checkpoint …

Eukaryotic genome integrity is safeguarded by two highly conserved protein kinases that are
called ATR and ATM for humans and Mec1 and Tel1 for Saccharomyces cerevisiae …

Cells respond to DNA or mitotic spindle damage by activating specific pathways that halt the
cell cycle to allow for possible repair. Here, we report that inactivation of one of the …

DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, because
failure to repair them can lead to genome rearrangements or chromosome loss. They can …

Анализ радиочувствительности двойных мутантов у дрожжей Saccharomyces
cerevisiae показал, что чекпойнт-гены RAD9, RAD17, RAD24, RAD53, а также гены …

Abstract Analysis of radiosensitivity of double mutants in the yeast Saccharomyces
cerevisiae revealed that checkpoint genes RAD9, RAD17, RAD24, and RAD53 along with …

Анализ радиочувствительности двойных мутантов показал, что гены регуляции в
сверочной точке, или чекпойнт-гены, RAD9, RAD17, RAD24, RAD53, а также гены …

Eukaryotic cells repair DNA double-strand breaks (DSBs) through both non-homologous
and homologous recombination pathways. The initiation of homologous recombination …

Recombination is an essential component in the scheme of events that maintain telomeric
homeostasis. I have been interested in understanding the recombination events that lead to …