Several recent studies have emphasized a crucial role for the interactions between
serotonergic and dopaminergic systems in movement control and the pathophysiology of …

Abstract Serotonin (5-hydroxytryptamine, or 5-HT) is strongly implicated in the ability to shift
behavior in response to changing stimulus-reward contingencies. However, there is little …

Agonist activation of central 5‐HT2A receptors results in diverse effects, such as
hallucinations and changes of consciousness. Recent findings indicate that activation of the …

(±)-3, 4-Methylenedioxymethamphetmine (MDMA, or Ecstasy) is an illicit drug that evokes
transporter-mediated release of monoamines, including serotonin (5-HT) and dopamine …

A comprehensive, state-of-the-art review of our current understanding of the molecular and
structural biology of 5-HT receptors and their potential use for drug discovery. The authors …

Variability in expression of the 5-HT transporter (5-HTT) gene in the human population has
been associated with a range of behavioural phenotypes. The underlying mechanisms are …

Radiochemical labeling of MDL 105725 using the secondary labeling precursor 2-[18F]
fluoroethyltosylate ([18F] FETos) was carried out in yields of∼ 90% synthesizing [18F] …

Induction of mRNA or protein for immediate–early genes, such as c-fos, is used to identify
brain areas, specific cell types, and neuronal circuits that become activated in response to …

An in vivo binding assay is characterized for [3H] M100907 binding to rat brain, as a
measure of 5-HT2A receptor occupancy. Dose–response analyses were performed for …

Serotonergic neurons located in the dorsal and median raphe nuclei innervate the whole
neuraxis and are critically involved in a large number of physiological functions, including …