Outcomes for COPD pharmacological trials: from lung function to biomarkers

M Cazzola, W MacNee, FJ Martinez… - European respiratory …, 2008 - Eur Respiratory Soc
The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …

Morphological and functional imaging in COPD with CT and MRI: present and future

J Ley-Zaporozhan, S Ley, HU Kauczor - European radiology, 2008 - Springer
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity
and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a …

Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia

PM Wong, AN Lees, J Louw, FY Lee… - European …, 2008 - Eur Respiratory Soc
Improved survival following extreme preterm birth complicated by bronchopulmonary
dysplasia (BPD) is resulting in an increasing number of affected infants surviving to …

Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease

BD Patel, HO Coxson, SG Pillai… - American journal of …, 2008 - atsjournals.org
Rationale: It is unclear whether airway wall thickening and emphysema make independent
contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and …

Quantitative assessment of emphysema, air trapping, and airway thickening on computed tomography

YK Lee, YM Oh, JH Lee, EK Kim, JH Lee, N Kim… - Lung, 2008 - Springer
The severity of chronic obstructive pulmonary disease (COPD) is evaluated not only by
airflow limitation but also by factors such as exercise capacity and body mass index. Recent …

Quantitative assessment of air trapping in chronic obstructive pulmonary disease using inspiratory and expiratory volumetric MDCT

S Matsuoka, Y Kurihara, K Yagihashi… - American Journal of …, 2008 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of our study was to determine the attenuation threshold value for
the detection and quantification of air trapping using paired inspiratory and expiratory …

Texture-based quantification of pulmonary emphysema on high-resolution computed tomography: comparison with density-based quantification and correlation with …

YS Park, JB Seo, N Kim, EJ Chae, YM Oh… - Investigative …, 2008 - journals.lww.com
Purpose: To develop a system for texture-based quantification of emphysema on high-
resolution computed tomography (HRCT) and to compare it with density-based …

Quantitative computed tomography assessment of airway wall dimensions: current status and potential applications for phenotyping chronic obstructive pulmonary …

HO Coxson - Proceedings of the American Thoracic Society, 2008 - atsjournals.org
Airway remodeling is extremely important in the pathophysiology of chronic obstructive
pulmonary disease (COPD). Since the site and nature of airflow obstruction was described …

Exhaled breath condensate 8-isoprostane, clinical parameters, radiological indices and airway inflammation in COPD

D Makris, E Paraskakis, P Korakas, E Karagiannakis… - Respiration, 2008 - karger.com
Background: Exhaled breath condensate (EBC) 8-isoprostane levels were found increased
in chronic obstructive pulmonary disease. However, the relation between EBC 8-isoprostane …

Pulmonary Emphysema: Size Distribution of Emphysematous Spaces on Multidetector CT Images—Comparison with Macroscopic and Microscopic Morphometry1

A Madani, A Van Muylem, V De Maertelaer, J Zanen… - Radiology, 2008 - pubs.rsna.org
Purpose: To test the hypothesis that the frequency-size distribution of low-attenuation areas
could be a parameter to quantify pulmonary emphysema. Materials and Methods: Ethics …