The therapeutic arsenal for the treatment of Alzheimer's disease (AD) remains confined to a
group of four inhibitors of AChE and one NMDA receptor antagonist, which are used to …

Memory, attention and creativity represent three different cognitive domains, which are
interconnected and contribute the “mental performance” of an individual. Modern …

A novel series of donepezil− tacrine hybrids designed to simultaneously interact with the
active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been …

In the course of screening for acetylcholinesterase and butyrylcholinesterase inhibitors from
natural products by an in vitro Ellman method, the extract of the roots of Vitis amurensis …

Alzheimer's disease (AD) is becoming an increasingly heavy burden on the society of
developed countries, and physicians now face the challenge of providing efficient treatment …

The complex etiology of Alzheimer's disease (AD) prompts scientists to develop multitarget
strategies to combat causes and symptoms. We therefore designed, synthesized, and tested …

In this contribution, from a coumarin library consisting of 29 compounds including natural
and synthetic derivatives, an active acetylcholinesterase (AChE) inhibitor (coumarin 106) …

Acetylcholine was the first neurotransmitter identified and ATP is the hitherto final compound
added to the list of small molecule neurotransmitters. Despite the wealth of evidence …

A number of mono-and bis-quaternary ammonium salts, containing edrophonium-like and
coumarin moieties tethered by an appropriate linker, proved to be highly potent and …

Protein conformational fluctuations are critical for biological functions, although the
relationship between protein motion and function has yet to be fully explored. By a thorough …