Resistance to antifungal agents: mechanisms and clinical impact

ZA Kanafani, JR Perfect - Clinical infectious diseases, 2008 - academic.oup.com
Despite advances in preventive, diagnostic, and therapeutic interventions, invasive fungal
infections cause significant morbidity and mortality in immunocompromised patients. The …

Changing epidemiology of systemic fungal infections

M Richardson, C Lass‐Flörl - Clinical microbiology and …, 2008 - Wiley Online Library
ABSTRACT Species of Candida and Aspergillus remain the most common causes of
invasive fungal infections, but other yeasts and filamentous fungi are emerging as significant …

Patients at high risk of invasive fungal infections: when and how to treat

MJGT Rüping, JJ Vehreschild, OA Cornely - Drugs, 2008 - Springer
When and how to treat invasive fungal infections (IFIs) is discussed in this review, with a
focus on the two most prevalent non-endemic IFIs, namely invasive aspergillosis and …

Factors Associated with Candidemia Caused by Non-albicans Candida Species Versus Candida albicans in the Intensive Care Unit

JK Chow, Y Golan, R Ruthazer… - Clinical infectious …, 2008 - academic.oup.com
Background. Candida albicans has been the most common cause of fungal bloodstream
infections (BSIs) in intensive care units (ICUs); however, infections due to non-albicans …

Current challenges in the management of invasive fungal infections

CC Lai, CK Tan, YT Huang, PL Shao… - Journal of Infection and …, 2008 - Elsevier
The incidence of invasive fungal infections (IFIs) has increased over the past two decades,
as the populations of patients at risk have continued to rise. Early and accurate diagnosis …

Candidemia in nonneutropenic critically ill patients: risk factors for non-albicans Candida spp.

EG Playford, D Marriott, Q Nguyen, S Chen… - Critical care …, 2008 - journals.lww.com
Objective: The objective of this study was to determine the clinical features associated with
candidemia caused by non-albicans Candida spp. and with potentially fluconazole-resistant …

Trends in Species Distribution and Susceptibility of Bloodstream Isolates of Candida Collected in Monterrey, Mexico, to Seven Antifungal Agents: Results of a 3-Year …

GM González, M Elizondo, J Ayala - Journal of clinical …, 2008 - Am Soc Microbiol
During a 3-year surveillance program (2004 to 2007) in Monterrey, Mexico, 398 isolates of
Candida spp. were collected from five hospitals. We established the species distribution and …

Risk factors for albicans and non-albicans candidemia in the intensive care unit

JK Chow, Y Golan, R Ruthazer, AW Karchmer… - Critical care …, 2008 - journals.lww.com
Objective: To determine risk factors for bloodstream infections (BSI) with Candida non-
albicans (C-NA) species and Candida albicans (CA) among critically ill patients. Design …

Characteristics of biofilm formation by Candida tropicalis and antifungal resistance

FC Bizerra, CV Nakamura, C De Poersch… - FEMS yeast …, 2008 - academic.oup.com
Candida tropicalis is a common species related to nosocomial candidemia and candiduria.
Most Candida spp. infections are associated with biofilm formation on implanted medical …

Antifungal serum concentration monitoring: an update

ML Goodwin, RH Drew - Journal of Antimicrobial Chemotherapy, 2008 - academic.oup.com
Invasive fungal infections (IFIs) are occurring with increasing incidence and are associated
with significant morbidity and mortality. Understanding the relationship between the …