Regulation of apoptosis by PML and the PML-NBs
The promyelocytic leukemia protein (PML) is a tumor suppressor identified in acute PML and
implicated in the pathogenesis of a variety of tumors. PML is essential for the proper …
implicated in the pathogenesis of a variety of tumors. PML is essential for the proper …
Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX …
The mechanisms underlying deregulation of HOX gene expression in AML are poorly
understood. The ParaHox gene CDX2 was shown to act as positive upstream regulator of …
understood. The ParaHox gene CDX2 was shown to act as positive upstream regulator of …
Auranofin promotes retinoic acid‐ or dihydroxyvitamin D3‐mediated cell differentiation of promyelocytic leukaemia cells by increasing histone acetylation
Background and purpose: To investigate the molecular mechanism for the effect of auranofin
on the induction of cell differentiation, the cellular events associated with differentiation were …
on the induction of cell differentiation, the cellular events associated with differentiation were …
[HTML][HTML] Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
EM Rego, BAA Santana-Lemos… - Revista Brasileira de …, 2008 - SciELO Brasil
Differentiation syndrome is a treatment complication which can occur in acute promyelocytic
leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO) …
leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO) …
Identification of novel and direct target genes of p73
E Lapi - 2008 - art.torvergata.it
The p53 paralogues p73, p63 and their respective truncated isoforms have been shown to
be critical regulators of developmental and differentiation processes. Indeed, both p73 and …
be critical regulators of developmental and differentiation processes. Indeed, both p73 and …
Síndrome da diferenciação na leucemia promielocítica aguda: patogênese e fatores de risco
EM Rego, BAA Santana-Lemos… - Revista Brasileira de …, 2008 - SciELO Brasil
Differentiation syndrome is a treatment complication which can occur in acute promyelocytic
leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO) …
leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO) …
Chromatin alterations imposed by the oncogenic transcription factor PML-RAR
L Morey Ramonell - 2008 - tdx.cat
In mammals, as in plants, mutations in SNF2-like DNA helicases/ATPases were shown to
affect not only chromatin structure but also global methylation patterns, suggesting a …
affect not only chromatin structure but also global methylation patterns, suggesting a …
[PDF][PDF] Genexpressionsanalysen von CD34+ hämatopoietischen Stamm-und Progenitorzellen bei Patienten mit Polycythaemia vera
TM Schroeder - 2008 - docserv.uni-duesseldorf.de
Die Polycythaemia vera (PV) wurde 1892 von Vaquez zum ersten Mal beschrieben und
gehört neben der chronischen myeloischen Leukämie (CML), der essentiellen …
gehört neben der chronischen myeloischen Leukämie (CML), der essentiellen …