The mitochondrial life cycle consists of frequent fusion and fission events. Ample
experimental and clinical data demonstrate that inhibition of either fusion or fission results in …

Mitochondrial components are continuously distributed throughout the whole chondriome of
a cell by fusion and fission. Thus, a single mitochondrion represents a transient fraction of …

Neurons concentrate mitochondria at sites in the cell that have a high demand for ATP
and/or calcium buffering. To accomplish this, mitochondrial transport and docking are …

Autosomal dominant optic atrophy (ADOA), the commonest cause of inherited optic atrophy,
is caused by mutations in the ubiquitously expressed gene optic atrophy 1 (OPA1), involved …

Mitochondrial diseases can present with signs in almost any organ. Well planned clinical
evaluation is the key to successful diagnostic work-up of mitochondrial diseases. An …

Background Autosomal dominant optic atrophy (ADOA), a form of progressive bilateral
blindness due to loss of retinal ganglion cells and optic nerve deterioration, arises …

Structural instability of mitochondrial DNA (mtDNA), consisting either of large-scale
rearrangements, tissuespecific depletion or both, is a major cause of mitochondrial …

Mitochondrial diseases encompass an extraordinary assemblage of clinical problems,
commonly involving tissues that have high energy requirements, such as retina, brain, heart …

Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (DOA) are
the two most common inherited optic neuropathies and they result in significant visual …

It is well accepted that many pathological neurodegenerative diseases are mediated, at
least in part, by programmed cell death or apoptosis. A variety of mechanisms that lead to …