Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic
transplantation, hepatic resection, and trauma. The signaling events contributing to local …

Steatosis of the liver may arise from a variety of conditions, but the molecular basis for lipid
droplet formation is poorly understood. Although a certain amount of lipid storage may even …

Acute liver failure (ALF) shares striking similarities with septic shock with regard to the
features of systemic inflammation, progression to multiple organ dysfunction and functional …

The greatest part of liver allograft injury occurs during reperfusion, not during the cold
ischemia phase. The aim of this study, therefore, was to investigate how the severity of …

Ischemia and reperfusion injury is a dynamic process that involves multiple organ systems in
various clinical states including transplantation, trauma, and surgery. Research into this field …

CXC chemokines and their receptor, CXC chemokine receptor‐2 (CXCR2), are important
components of the hepatic inflammatory response to ischemia/reperfusion (I/R). However …

Background. Mechanisms mediating CD4+ T-cell recruitment during alloantigen-
independent hepatic ischemia-reperfusion (I/R) remain not fully understood. We …

Heart failure is a very serious cardiovascular disease that affects more than five million
people in North America. The role of cytochrome P450 (CYP) in cardiovascular health and …

Ischemia and reperfusion injury (IRI) contributes to the development of chronic interstitial
fibrosis/tubular atrophy in renal allograft patients. Cyclooxygenase (COX) 1 and 2 actively …

Oxidative stress is a common feature in most hepatopathies. In recent years, evidence has
accumulated that reactive oxygen species (ROS) induce a number of functional changes …