The role of NKT cells in tumor immunity

M Terabe, JA Berzofsky - Advances in cancer research, 2008 - Elsevier
NKT cells are a relatively newly recognized member of the immune community, with
profound effects on the rest of the immune system despite their small numbers. They are true …

[HTML][HTML] Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans

C De Santo, M Salio, SH Masri… - The Journal of …, 2008 - Am Soc Clin Investig
Infection with influenza A virus (IAV) presents a substantial threat to public health worldwide,
with young, elderly, and immunodeficient individuals being particularly susceptible …

Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma

GJ Renukaradhya, MA Khan, M Vieira… - Blood, The Journal …, 2008 - ashpublications.org
Natural killer T (NKT) cells are a T-cell subpopulation known to possess immunoregulatory
functions and recognize CD1d molecules. The majority of NKT cells express an invariant T …

Methods for detection, isolation and culture of mouse and human invariant NKT cells

H Watarai, R Nakagawa, M Omori-Miyake… - Nature protocols, 2008 - nature.com
This protocol describes methods to identify, purify and culture CD1d restricted invariant
natural killer T (i NKT) cells from mouse tissue or human blood samples. The methods for …

Activation of invariant NKT cells enhances the innate immune response and improves the disease course in influenza A virus infection

LP Ho, L Denney, K Luhn, D Teoh… - European journal of …, 2008 - Wiley Online Library
Invariant NKT (iNKT) cells have an indubitable role in antiviral immunity, although the
mechanisms by which these cells exert their functions are not fully elucidated. With the …

Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants

S Kim, S Lalani, VV Parekh, L Wu… - Expert review of …, 2008 - Taylor & Francis
Invariant natural killer T (iNKT) cells are a unique subset of T lymphocytes that recognize
glycolipid antigens in the context of the antigen-presenting molecule CD1d. Upon glycolipid …

Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells

JD Silk, M Salio, BG Reddy, D Shepherd… - The Journal of …, 2008 - journals.aai.org
Invariant NKT cells (iNKT cells) recognize CD1d/glycolipid complexes. We demonstrate that
the nonglycosidic compound threitolceramide efficiently activates iNKT cells, resulting in …

Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors

S Patterson, A Chaidos, DCA Neville… - The Journal of …, 2008 - journals.aai.org
Invariant NKT (iNKT) cells are a subset of highly conserved immunoregulatory T cells that
modify a variety of immune responses, including alloreactivity. Central to their function is the …

CD1d presentation of glycolipids

AO Speak, V Cerundolo, FM Platt - Immunology and cell …, 2008 - Wiley Online Library
The CD1 family of antigen‐presenting molecules consists of five members, CD1a to e. Of
these molecules CD1d has been the subject of much interest over the past 10 years …

Role of invariant natural killer T (iNKT) cells in systemic lupus erythematosus

M Godó, T Sessler, P Hamar - Current medicinal chemistry, 2008 - ingentaconnect.com
Natural killer T (NKT) cells represent a unique T cell lineage. The NKT cells bearing an
invariant TCR (iNKT cells) recognize a small variety of glycolipid antigens in the context of …