Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

Interstitial telomeric sequences (ITSs) consist of tandem repeats of the canonical telomeric
repeat and are common in mammals. They are localized at intrachromosomal sites …

Purpose: About 15% of colorectal cancers harbor microsatellite instability (MSI). MSI-
associated gene expression changes have been identified in colorectal cancers, but little …

Colorectal cancer (CRC) is a complex and heterogeneous disease in which genomic
instability and DNA promoter methylation play important roles. The aim of this study was to …

The overall survival of gastric cancer patients remains poor despite efforts and advances in
its prevention, diagnosis, and treatment. The development of new therapies is crucial for the …

Aims: MYH is a DNA glycosylase in the base excision repair pathway. Germ‐line biallelic
mutations in the MYH gene are associated with the development of multiple colorectal …

AIM: To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-
phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary …

Although microsatellite mutation rates generally increase with increasing length of the
repeat tract, interruptions in a microsatellite may stabilize it. We have performed a direct …

Consumption of fruits and vegetables that contain many non-nutritive and nutritive
compounds is associated with decreased risk of several types of cancer, including CRC …