Cell and biomolecular mechanics in silico

AA VAziri, AV GopinAth - Nature materials, 2008 - nature.com
Recent developments in computational cell and biomolecular mechanics have provided
valuable insights into the mechanical properties of cells, subcellular components and …

The effect of geometry on three-dimensional tissue growth

M Rumpler, A Woesz, JWC Dunlop… - Journal of the …, 2008 - royalsocietypublishing.org
Tissue formation is determined by uncountable biochemical signals between cells; in
addition, physical parameters have been shown to exhibit significant effects on the level of …

Endothelial cell–matrix interactions in neovascularization

ME Francis, S Uriel, EM Brey - Tissue Engineering Part B: Reviews, 2008 - liebertpub.com
The success of many therapies in regenerative medicine requires the ability to control the
formation of stable vascular networks within tissues. The formation of new blood vessels, or …

[HTML][HTML] Tissue deformation modulates twist expression to determine anterior midgut differentiation in Drosophila embryos

N Desprat, W Supatto, PA Pouille, E Beaurepaire… - Developmental cell, 2008 - cell.com
Mechanical deformations associated with embryonic morphogenetic movements have been
suggested to actively participate in the signaling cascades regulating developmental gene …

Osteocyte morphology in fibula and calvaria—is there a role for mechanosensing?

A Vatsa, RG Breuls, CM Semeins, PL Salmon, TH Smit… - Bone, 2008 - Elsevier
INTRODUCTION: External mechanical forces on cells are known to influence cytoskeletal
structure and thus cell shape. Mechanical loading in long bones is unidirectional along their …

Two characteristic regimes in frequency-dependent dynamic reorientation of fibroblasts on cyclically stretched substrates

S Jungbauer, H Gao, JP Spatz, R Kemkemer - Biophysical journal, 2008 - cell.com
Cells adherent on a cyclically stretched substrate with a periodically varying uniaxial strain
are known to dynamically reorient nearly perpendicular to the strain direction. We …

[HTML][HTML] Scaffold stiffness influences cell behavior: opportunities for skeletal tissue engineering

RGM Breuls, TU Jiya, TH Smit - The open orthopaedics journal, 2008 - ncbi.nlm.nih.gov
Skeletal defects resulting from trauma, tumors, or abnormal development frequently require
surgical treatment to restore normal tissue function. To overcome the limitations associated …

[HTML][HTML] Mechano-coupling and regulation of contractility by the vinculin tail domain

CT Mierke, P Kollmannsberger, DP Zitterbart, J Smith… - Biophysical journal, 2008 - cell.com
Vinculin binds to multiple focal adhesion and cytoskeletal proteins and has been implicated
in transmitting mechanical forces between the actin cytoskeleton and integrins or cadherins …

Enhancement of in vitro capillary tube formation by substrate nanotopography

CJ Bettinger, Z Zhang, S Gerecht… - Advanced …, 2008 - Wiley Online Library
Endothelial progenitor cells are cultured on nanotopographic substrates with a line‐grating
geometry and respond to these substrates through aligned and elongated morphology …

Engineered nanoforce gradients for inhibition of settlement (attachment) of swimming algal spores

JF Schumacher, CJ Long, ME Callow, JA Finlay… - Langmuir, 2008 - ACS Publications
Current antifouling strategies are focused on the development of environmentally friendly
coatings that protect submerged surfaces from the accumulation of colonizing organisms (ie …