Inflammation underlies a wide variety of physiological and pathological processes. Although
the pathological aspects of many types of inflammation are well appreciated, their …

Around the same time that representatives of national governments met in Bali to discuss the
world climate and the Kyoto protocol on carbon dioxide emissions, IASP council, at its …

A cardinal feature of inflammation is heightened pain sensitivity at the site of the inflamed
tissue. This results from the local release by immune and injured cells of nociceptor …

Chronic pain patients suffer from more than just pain; depression and anxiety, sleep
disturbances, and decision-making abnormalities also significantly diminish their quality of …

Recently, local morphologic alterations of the brain in areas ascribable to the transmission of
pain were detected in patients suffering from phantom pain, chronic back pain, irritable bowl …

Peripheral pain pathways are activated by a range of stimuli. We used diphtheria toxin to kill
all mouse postmitotic sensory neurons expressing the sodium channel Nav1. 8. Mice …

The vanilloid receptor TRPV1 has been identified as a molecular target for the treatment of
pain associated with inflammatory diseases and cancer. Hence, TRPV1 antagonists have …

Some embodiments of the present invention provide stimu lation systems and components
for selective stimulation and/or neuromodulation of one or more nerve root ganglia through …

Environmental stimuli such as temperature and pressure are sensed by dorsal root ganglion
(DRG) neurons. DRG neurons are heterogeneous, but molecular markers that identify …

In the last decade, studies of transient receptor potential (TRP) channels, a superfamily of
cation-conducting membrane proteins, have significantly extended our knowledge about the …