Heme-iron oxygenases: powerful industrial biocatalysts?

MK Julsing, S Cornelissen, B Bühler… - Current opinion in chemical …, 2008 - Elsevier
Are cytochrome P450 enzymes powerful industrial biocatalysts? Next to market demands,
well-defined enzyme functionalities and process parameters allow generalizations on the …

Dioxygenase- and monooxygenase-catalysed synthesis of cis-dihydrodiols, catechols, epoxides and other oxygenated products

LC Nolan, KE O'Connor - Biotechnology letters, 2008 - Springer
Oxidoreductases are an emerging class of biotechnologically relevant enzymes due to their
regio-and stereo-specificity. The selective oxygenation of aromatic compounds by …

Metabolic response of Pseudomonas putida during redox biocatalysis in the presence of a second octanol phase

LM Blank, G Ionidis, BE Ebert, B Bühler… - The FEBS …, 2008 - Wiley Online Library
A key limitation of whole‐cell redox biocatalysis for the production of valuable, specifically
functionalized products is substrate/product toxicity, which can potentially be overcome by …

Metabolic capacity estimation of Escherichia coli as a platform for redox biocatalysis: constraint‐based modeling and experimental verification

LM Blank, BE Ebert, B Bühler… - Biotechnology and …, 2008 - Wiley Online Library
Whole‐cell redox biocatalysis relies on redox cofactor regeneration by the microbial host.
Here, we applied flux balance analysis based on the Escherichia coli metabolic network to …

NADH Availability Limits Asymmetric Biocatalytic Epoxidation in a Growing Recombinant Escherichia coli Strain

B Bühler, JB Park, LM Blank… - Applied and …, 2008 - Am Soc Microbiol
Styrene can efficiently be oxidized to (S)-styrene oxide by recombinant Escherichia coli
expressing the styrene monooxygenase genes styAB from Pseudomonas sp. strain VLB120 …

In situ recovery of lycopene during biosynthesis with recombinant Escherichia coli

KW Yoon, EH Doo, SW Kim, JB Park - Journal of biotechnology, 2008 - Elsevier
Lycopene is produced by recombinant Escherichia coli expressing genes to encode for the
lycopene biosynthesis. However, the productivity of lycopene seemed to be limited by many …

Biooxidations in chiral synthesis

MD Mihovilovic, DA Bianchi - … , Wiley-VCH Verlag GmbH & Co …, 2008 - books.google.com
Enzyme-mediated oxidation reactions offer highly diverse options for the modification of
existing functional groups as well as for the introduction of novel function in chiral catalysis …

Bioconversion of small molecules by cytochrome P450 species expressed in Escherichia coli

T Uno, S Okamoto, S Masuda, A Itoh… - Biotechnology and …, 2008 - Wiley Online Library
P450 (cytochrome P450) enzymes catalyse the mono‐oxygenation of a wide range of
compounds such as steroids, fatty acids, vitamins and drugs. In the present paper we …

Novel auto-inducing expression systems for the development of whole-cell biocatalysts

P Di Gennaro, S Ferrara, G Bestetti, G Sello… - Applied microbiology …, 2008 - Springer
Novel expression systems for the development of whole-cell biocatalysts were generated.
Their novelty consists both in the host, Pseudomonas putida, and in the ability to auto …

[PDF][PDF] Ganzzellbiotransformationen mit rekombinanten Escherichia coli zur Synthese chiraler Alkohole

K Schroer - 2008 - core.ac.uk
Whole cell biotransformation processes are of special interest for the synthesis of chiral
compounds since microorganisms offer some advantages in comparison to chemical …