There has been a long debate about the predominant involvement of the different adenosine
receptor subtypes and the preferential role of pre‐versus post‐synaptic mechanisms in the …

The interest on targeting adenosine A2A receptors in the realm of psychiatric diseases first
arose based on their tight physical and functional interaction with dopamine D2 receptors …

Psychostimulants and other drugs of abuse activate extracellular signal-regulated kinase
(ERK) in the striatum, through combined stimulation of dopamine D 1 receptors (D1Rs) and …

Phosphodiesterase (PDE) is a critical regulator of cAMP/protein kinase A (PKA) signaling in
cells. Multiple PDEs with different substrate specificities and subcellular localization are …

l‐3, 4‐Dihydroxyphenylalanine (l‐dopa) remains the most effective pharmacological
treatment for relief of the severe motor impairments of Parkinson's disease. It is very effective …

Rhes is a small GTP-binding protein prominently localized in the striatum. Previous findings
obtained in cell culture systems demonstrated an involvement of Rhes in cAMP/PKA …

Amphetamines, including methamphetamine, pose a significant cost to society due to
significant numbers of amphetamine-abusing individuals who suffer major health-related …

Introduction 3. The role of dopaminergic and glutamatergic neurotransmission in
schizophrenia 3.1. Involvement of glutamate N-methyl-D-aspartate (NMDA) receptors in the …

The dopamine system plays an important role in the regulation of attention and motor
behavior, subsequently, several dopamine-related genes have been associated with …

Dopamine D1‐like receptors play a key role in dopaminergic signaling. In addition to
Gs/olf/adenylyl cyclase (AC)‐coupled D1 receptors, the presence of D1‐like receptors …