The multi-step process of the emigration of cells from the blood stream through the vascular
endothelium into the tissue has been termed extravasation. The extravasation of leukocytes …

Immune-mediated inflammation in the retina is regulated by a combination of anatomical,
physiological and immuno-regulatory mechanisms, referred to as the blood–retina barrier …

The means by which the chemokine CCL2 produced in the brain parenchyma can recruit
leukocytes lying behind the highly impervious endothelium of the blood–brain barrier (BBB) …

Inflammatory bowel disease is characterized by the recruitment of lymphocytes to the gut via
mucosal vessels. Chemokines are believed to trigger α4β1-and α4β7-integrin-mediated …

Over the past 25 years, there have been dramatic changes in the management of diabetes
and its complications resulting from the application of evidence from randomized controlled …

The proteoglycan CD44 is a widely expressed cell surface receptor for the extracellular
matrix glycosaminoglycan hyaluronan, and is involved in processes ranging from metastasis …

The influence of the sub-endothelial basement membrane (BM) on the adhesion and
migration of leukocytes is not well-defined. We therefore investigated the behaviour of …

The concept of forbidden foods that should not be eaten goes back to the Garden of Eden
and apart from its religious meanings it may also have foreshadowed the concept of foods …

The neutrophil is the most abundant circulating leucocyte. It is derived from pluripotential
stem cells in the bone marrow and is characterized by the presence of a multilobed nucleus …

Phosphorylation of G protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) and the
subsequent recruitment of arrestin is a well-established paradigm that initiates the process …