Thrombin generation testing in routine clinical practice: are we there yet?

JJ Van Veen, A Gatt, M Makris - British journal of haematology, 2008 - Wiley Online Library
Thrombin is the central enzyme in the coagulation cascade. Estimation of an individual's
potential to generate thrombin may correlate more closely with a hyper‐or hypo‐coagulable …

Protein S deficiency: a clinical perspective

MK Ten Kate, J van der Meer - Haemophilia, 2008 - Wiley Online Library
Protein S (PS) is an extensively studied protein with an important function in the down‐
regulation of thrombin generation. Because of the presence of a pseudogene and two …

[HTML][HTML] Coagulation factors and the protein C system as determinants of thrombin generation in a normal population

A Dielis, E Castoldi, HMH Spronk, R Van Oerle… - Journal of Thrombosis …, 2008 - Elsevier
Background: Thrombin generation is a powerful tool to probe overall plasma coagulability.
Objective: To determine which plasma factors influence the various parameters of the …

Regulation of coagulation by protein S

E Castoldi, TM Hackeng - Current opinion in hematology, 2008 - journals.lww.com
Regulation of coagulation by protein S : Current Opinion in Hematology Regulation of
coagulation by protein S : Current Opinion in Hematology Log in or Register Subscribe to …

The haemostatic role of tissue factor pathway inhibitor

JTB Crawley, DA Lane - Arteriosclerosis, thrombosis, and vascular …, 2008 - Am Heart Assoc
Under normal conditions the blood circulates freely within the confines of the vascular
system, carrying oxygen, nutrients, and hormonal information around the body and removing …

Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency

C Duckers, P Simioni, L Spiezia, C Radu… - Blood, The Journal …, 2008 - ashpublications.org
Severe factor V (FV) deficiency is associated with mild to severe bleeding diathesis, but
many patients with FV levels lower than 1% bleed less than anticipated. We used calibrated …

Aetiology and management of extrahepatic portal vein obstruction in children: King's College Hospital experience

N Abd El-hamid, RM Taylor, D Marinello… - Journal of pediatric …, 2008 - journals.lww.com
Objective: To study a single-centre experience of the management of extrahepatic portal
vein obstruction (EHPVO) in children during the last 3 decades. Materials and Methods: The …

Standardization and clinical utility of thrombin-generation assays

E Berntorp, GL Salvagno - Seminars in thrombosis and …, 2008 - thieme-connect.com
Thrombin generation is a key process that determines the extent of a hemostatic plug or a
thrombotic process. The ensuing thrombin burst is crucial for the formation of a stable fibrin …

[HTML][HTML] Different effects of oral contraceptives containing different progestogens on protein S and tissue factor pathway inhibitor

H Van Vliet, RM Bertina, AEA Dahm… - Journal of Thrombosis …, 2008 - Elsevier
Background: Oral contraceptives (OC) containing different types of progestogens induce
different sensitivities to activated protein C (APC) measured with the thrombin generation …

Thrombin generation in patients after acute deep-vein thrombosis

AJ ten Cate-Hoek, AWJH Dielis… - Thrombosis and …, 2008 - thieme-connect.com
Thrombin generation measurement may be of value for assessing the risk of venous
thromboembolism, but its long term profile has not been assessed in patients. We evaluated …