Epigenetics in cancer
M Esteller - New England Journal of Medicine, 2008 - Mass Medical Soc
Gene transcription can be activated or inhibited by a reversible modification of the gene; this
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …
Roles of the EZH2 histone methyltransferase in cancer epigenetics
JA Simon, CA Lange - Mutation Research/Fundamental and Molecular …, 2008 - Elsevier
EZH2 is the catalytic subunit of Polycomb repressive complex 2 (PRC2), which is a highly
conserved histone methyltransferase that targets lysine-27 of histone H3. This methylated …
conserved histone methyltransferase that targets lysine-27 of histone H3. This methylated …
[PDF][PDF] Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
Cellular differentiation entails loss of pluripotency and gain of lineage-and cell-type-specific
characteristics. Using a murine system that progresses from stem cells to lineage-committed …
characteristics. Using a murine system that progresses from stem cells to lineage-committed …
Repression of E-cadherin by the polycomb group protein EZH2 in cancer
Enhancer of zeste homolog 2 (EZH2) is a critical component of the polycomb-repressive
complex 2 (PRC2), which is involved in gene silencing and histone H3 lysine 27 …
complex 2 (PRC2), which is involved in gene silencing and histone H3 lysine 27 …
A novel CpG island set identifies tissue-specific methylation at developmental gene loci
CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient
human genome and associate with many gene promoters. As CGIs also differ from bulk …
human genome and associate with many gene promoters. As CGIs also differ from bulk …
The social environment and the epigenome
The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications,
polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation …
polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation …
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
HM O'Hagan, HP Mohammad, SB Baylin - PLoS genetics, 2008 - journals.plos.org
Chronic exposure to inducers of DNA base oxidation and single and double strand breaks
contribute to tumorigenesis. In addition to the genetic changes caused by this DNA damage …
contribute to tumorigenesis. In addition to the genetic changes caused by this DNA damage …
[PDF][PDF] Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
J Lee, MJ Son, K Woolard, NM Donin, A Li, CH Cheng… - Cancer cell, 2008 - cell.com
Despite similarities between tumor-initiating cells with stem-like properties (TICs) and
normal neural stem cells, we hypothesized that there may be differences in their …
normal neural stem cells, we hypothesized that there may be differences in their …
Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line
EN Gal-Yam, G Egger, L Iniguez… - Proceedings of the …, 2008 - National Acad Sciences
Epigenetic reprogramming is commonly observed in cancer, and is hypothesized to involve
multiple mechanisms, including DNA methylation and Polycomb repressive complexes …
multiple mechanisms, including DNA methylation and Polycomb repressive complexes …