The role of the EGFR signaling in tumor microenvironment
A De Luca, A Carotenuto, A Rachiglio… - Journal of cellular …, 2008 - Wiley Online Library
The epidermal growth factor receptor (EGFR) family comprehends four different tyrosine
kinases (EGFR, ErbB‐2, ErbB‐3, and ErbB‐4) that are activated following binding to …
kinases (EGFR, ErbB‐2, ErbB‐3, and ErbB‐4) that are activated following binding to …
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions
S Barr, S Thomson, E Buck, S Russo, F Petti… - Clinical & experimental …, 2008 - Springer
Over 90% of all cancers are carcinomas, malignancies derived from cells of epithelial origin.
As carcinomas progress, these tumors may lose epithelial morphology and acquire …
As carcinomas progress, these tumors may lose epithelial morphology and acquire …
Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross‐talking with RANK signaling
T Yi, HL Lee, JH Cha, SI Ko, HJ Kim… - Journal of cellular …, 2008 - Wiley Online Library
The epidermal growth factor receptor (EGFR) functions in various cellular physiological
processes such as proliferation, differentiation, and motility. Although recent studies have …
processes such as proliferation, differentiation, and motility. Although recent studies have …
S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation
V Paruchuri, A Prasad, K McHugh, HK Bhat, K Polyak… - PloS one, 2008 - journals.plos.org
S100A7 is a small calcium binding protein, which has been shown to be differentially
expressed in psoriatic skin lesions, as well as in squamous cell tumors of the skin, lung and …
expressed in psoriatic skin lesions, as well as in squamous cell tumors of the skin, lung and …
Functions of normal and malignant prostatic stem/progenitor cells in tissue regeneration and cancer progression and novel targeting therapies
M Mimeault, PP Mehta, R Hauke, SK Batra - Endocrine reviews, 2008 - academic.oup.com
This review summarizes the recent advancements that have improved our understanding of
the functions of prostatic stem/progenitor cells in maintaining homeostasis of the prostate …
the functions of prostatic stem/progenitor cells in maintaining homeostasis of the prostate …
Genetic Polymorphism in EGF Is Associated with Prostate Cancer Aggressiveness and Progression-Free Interval in Androgen Blockade–Treated Patients
AL Teixeira, R Ribeiro, D Cardoso, D Pinto, F Lobo… - Clinical cancer …, 2008 - AACR
Purpose: Most prostate cancer patients develop resistance to androgen deprivation
treatment, resulting in hormone resistance. Epidermal growth factor (EGF) activates several …
treatment, resulting in hormone resistance. Epidermal growth factor (EGF) activates several …
Arachidonic acid modulates the crosstalk between prostate carcinoma and bone stromal cells
A Angelucci, S Garofalo, S Speca… - Endocrine-related …, 2008 - erc.bioscientifica.com
Diets high in n-6 fatty acids are associated with an increased risk of bone metastasis from
prostate carces (PCa). The molecular mechanism underlying this phenomenon is largely …
prostate carces (PCa). The molecular mechanism underlying this phenomenon is largely …
[PDF][PDF] Podstawy biologiczne terapii ukierunkowanej na receptor czynnika wzrostu naskórka (EGFR)
MZ Wojtukiewicz, M Rybałtowski… - Nowotwory. Journal of …, 2008 - journals.viamedica.pl
Uwagę zwraca wysoka (zbliżona do 100%) częstość występowania nadmiernej ekspresji
EGFR na komórkach nowotworów okolicy głowy i szyi. Wykazano, iż ekspresja EGFR jest 50 …
EGFR na komórkach nowotworów okolicy głowy i szyi. Wykazano, iż ekspresja EGFR jest 50 …
Recent advances in the development of novel anti‐cancer drugs targeting cancer stem/progenitor cells
M Mimeault, SK Batra - Drug Development Research, 2008 - Wiley Online Library
Recent advances in basic and clinical oncology have led to the identification and
characterization of several deregulated gene products involved in cancer progression to …
characterization of several deregulated gene products involved in cancer progression to …
Prolonged control of bone metastases in non-small-cell lung cancer patients treated with gefitinib
G Zampa, M Moscato, BW Brannigan, A Morabito… - Lung Cancer, 2008 - Elsevier
We describe two non-small-cell lung cancer (NSCLC) patients in which treatment with the
epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKIs) gefitinib produced a …
epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKIs) gefitinib produced a …