It has been shown that epigenetic modifications play an important role in tumorigenesis.
Thus, affecting epigenetic tumorigenic alterations can represent a promising strategy for …

Histone acetyltransferases (HATs) are a class of enzymes that participate in modulating
chromatin structure and gene expression. Altered HAT activity has been implicated in a …

The acuABC genes of Bacillus subtilis comprise a putative posttranslational modification
system. The AcuA protein is a member of the G cn5-related Na cetyl t ransferase (GNAT) …

The crystal structures of N-acetylglutamate synthase (NAGS) in the arginine biosynthetic
pathway of Neisseria gonorrhoeae complexed with acetyl-CoA and with CoA plus N …

After in vitro maturation, the unfertilized pig oocytes underwent the process called ageing.
This process involves typical events such as fragmentation, spontaneous parthenogenetic …

Maintenance of genomic integrity during antigen receptor gene rearrangements requires (1)
regulated access of the V (D) J recombinase to specific loci and (2) generation of double …

Beta-catenin is the key transcriptional activator of the Wnt pathway important for
development and tissue homeostasis of multicellular organisms. Its deregulation contributes …

Histone acetylation plays an important role in the assembly and regulation of chromatin
structure. The transfer of acetyl groups onto histone lysine residues is catalyzed by Histone …

Au cours de la maturation des gamètes mâles a lieu un événement unique: les structures
classiques qui ordonnent l'ADN sont complètement bouleversées et remplacées par une …

The present invention is directed to methods for inhibition of histone acetyltransferases
using glycosaminoglycans. The invention is further directed to methods for treating disorders …