Epigenetics and epigenomic medicine encompass a new science of brain and behavior that
are already providing unique insights into the mechanisms underlying brain development …

During brain development cells divide, differentiate and migrate to their assigned targets to
form synapses and active cell assemblies. This sequence is controlled both by genetic …

Cleft lip and cleft palate are frequent human congenital malformations with a complex
multifactorial etiology. These orofacial clefts can occur as part of a syndrome involving …

Neural stem cell quiescence is an important feature in invertebrate and mammalian central
nervous system development, yet little is known about the mechanisms regulating entry into …

The production of adult‐born neurons is an ongoing process accounting for> 10 000
immature neurons migrating to the olfactory bulb every day. This high turnover rate …

The role of the Ras/MEK/ERK pathway was examined in relation to DNA damage in human
multiple myeloma (MM) cells exposed to Chk1 inhibitors in vitro and in vivo. Exposure of …

Background In recent years, the molecular underpinnings of the long-observed resemblance
between neoplastic and immature tissue have begun to emerge. Genome-wide …

Mouse embryonic stem (ES) cells grown in feeder-free suspension cultures in the presence
of leukemia inhibitory factor (LIF) and basic fibroblast growth factor (bFGF) form spheres that …

GABAA receptor function is involved in regulating proliferation, migration, and differentiation
of rodent neural progenitor cells (NPCs). However, little is known about the molecular …

Mouse and human embryonic stem (mES and hES) cells have become one of the most
intensively studied primary cell types in biomedical research. However, culturing ES cells is …