Profound thrombocytopenia and microangiopathic hemolytic anemia characterize
thrombotic microangiopathy, which includes two major disorders: thrombotic …

Thrombotic thrombocytopenic purpura (TTP) is an acute, rare, life‐threatening disorder. This
report presents the South East (SE) England registry for TTP, from April 2002 to December …

BACKGROUND: From 20 to 50% of patients who survive an acute episode of the acquired
form of thrombotic thrombocytopenic purpura relapse but clinical and laboratory markers of …

Antiphospholipid syndrome (APS) is a disorder characterized by a wide variety of clinical
manifestations. Virtually any organ system or tissue may be affected by the consequences of …

Idiopathic thrombotic thrombocytopenic purpura (TTP) is characterized by frequent
recurrences. Effective screening for relapses will enable intervention prior to overt episodes …

Autoantibodies to ADAMTS13 (a disintegrin‐like and metalloprotease with thrombospondin
type I motif, member 13) play an important role in the development of microthrombosis in …

Thrombotic thrombocytopenic purpura (TTP) is a rare disease (5-10 cases per million
persons per year) characterised by the massive formation of platelet richthrombi in the …

Increasing awareness of the importance of aberrant B cell regulation in autoimmunity has
driven the clinical development of novel B cell-directed biologic therapies with the potential …

Despite progress in understanding the pathophysiology of thrombotic thrombocytopenic
purpura, acute bouts as well as relapses still represent serious health threats to patients and …

ABSTRACT von Willebrand factor (VWF) is a multimeric plasma protein that mediates
platelet adhesion and aggregation at sites of vascular injury and also acts as a protective …