Mammalian iron homeostasis must be meticulously regulated so that this essential element
is available for use, but at the same time prevented from promoting the formation of toxic …

Iron is an essential element in all living organisms and is required as a cofactor for oxygen-
binding proteins. Iron metabolism, oxygen homeostasis and erythropoiesis are consequently …

Mammalian microRNAs are emerging as key regulators of the development and function of
the immune system. Here, we report a strong but transient induction of miR-155 in mouse …

Hepcidin, a liver-derived protein that restricts enteric iron absorption, is the key regulator of
body iron content. Several proteins induce expression of the hepcidin-encoding gene Hamp …

Hypoxia-inducible factor (HIF) α, which has three isoforms, is central to the continuous
balancing of the supply and demand of oxygen throughout the body. HIF-α is a transcription …

В работе анализируются современные представления о гепсидине одном из основных
метаболитов феррокинетики и представлены впервые публикуемые собственные …

Circulating erythropoietin (EPO) is mainly produced by the kidneys and mediates
erythrogenesis in bone marrow and nonhematopoietic cell survival. EPO is also produced in …

Kidney disease is a frequent consequence of heavy metal exposure and renal anemia
occurs secondarily to the progression of kidney deterioration into chronic disease. In …

Idiopathic erythrocytosis is an uncommon disease, and is defined by an increase in red
blood cell mass. The differential diagnosis of erythrocytosis is extensive, and can be divided …

CD137 is a member of the TNFR family, and reverse signaling through the CD137 ligand,
which is expressed as a cell surface transmembrane protein, costimulates or activates …