Solid tumor physiology and hypoxia-induced chemo/radio-resistance: novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer

H Yasuda - Nitric Oxide, 2008 - Elsevier
Hypoxia exists in solid tumor tissues due to abnormal vasculature, vascular insufficiency,
treatment or malignancy related anemia, and low intratumor blood flow. Hypoxic status in …

Energy metabolism transition in multi‐cellular human tumor spheroids

S Rodríguez‐Enríquez… - Journal of cellular …, 2008 - Wiley Online Library
It is thought that glycolysis is the predominant energy pathway in cancer, particularly in solid
and poorly vascularized tumors where hypoxic regions develop. To evaluate whether …

Modelling the formation of necrotic regions in avascular tumours

MJ Tindall, CP Please, MJ Peddie - Mathematical biosciences, 2008 - Elsevier
The mechanisms underlying the formation of necrotic regions within avascular tumours are
not well understood. In this paper, we examine the relative roles of nutrient deprivation and …

[图书][B] Protein and cell therapy for lecithin-cholesterol acyltransferase (LCAT) deficiency

JK Low - 2008 - search.proquest.com
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme principally secreted by the liver
into the circulation where it esterifies cholesterol and plays a key role in high-density …