Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma
and Leishmania, which are human pathogens with devastating health and economic effects …

Comparative genomics of parasitic protists and their free-living relatives are profoundly
impacting our understanding of the regulatory systems involved in transcription and …

Trypanosoma brucei is a kinetoplastid flagellate, the agent of human sleeping sickness and
ruminant nagana in Africa. Kinetoplastid flagellates contain their eponym kinetoplast DNA …

Trypanosoma cruzi is the etiologic agent of Chagas' disease, an infection that affects several
million people in Latin America. With no immediate prospect of a vaccine and problems …

Autophagy is the major mechanism used by eukaryotic cells to degrade and recycle proteins
and organelles. Bioinformatics analysis of the genome of the protozoan parasite …

African trypanosomes, early diverged eukaryotes and the agents of sleeping sickness, have
several basic cellular processes that are remarkably divergent from those in their …

Protozoan Kinetoplastida, a group that comprises the pathogenic Trypanosoma brucei,
compartmentalize several metabolic systems such as the major part of the glycolytic …

Secreted cysteine proteases are relevant actors in parasite biology, taking part in critical
host colonization roles such as traversing tissue barriers, immune evasion and nutrient …

Background Different proteins are required in widely different quantities to build a living cell.
In most organisms, transcription control makes a major contribution to differential …

TLR9 is critical in parasite recognition and host resistance to experimental infection with
Trypanosoma cruzi. However, no information is available regarding nucleotide sequences …