Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon

JW Rowland, GWJ Hawryluk, B Kwon, MG Fehlings - Neurosurgical focus, 2008 - thejns.org
This review summarizes the current understanding of spinal cord injury pathophysiology and
discusses important emerging regenerative approaches that have been translated into …

[HTML][HTML] Stem cells for spinal cord repair

F Barnabé-Heider, J Frisén - Cell stem cell, 2008 - cell.com
Spinal cord injury typically results in permanent disability. Many studies have indicated that
transplantation of several different types of stem cells promotes functional recovery in animal …

Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial

A Mackay-Sim, F Feron, J Cochrane… - Brain, 2008 - academic.oup.com
Olfactory ensheathing cells show promise in preclinical animal models as a cell
transplantation therapy for repair of the injured spinal cord. This is a report of a clinical trial of …

Stem cell clinics online: the direct-to-consumer portrayal of stem cell medicine

D Lau, U Ogbogu, B Taylor, T Stafinski, D Menon… - Cell stem cell, 2008 - cell.com
Despite the immature state of stem cell medicine, patients are seeking and accessing
putative stem cell therapies in an" early market" in which direct-to-consumer advertising via …

Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury: A review

GWJ Hawryluk, J Rowland, BK Kwon, MG Fehlings - Neurosurgical focus, 2008 - thejns.org
Over the past 2 decades, advances in understanding the pathophysiology of spinal cord
injury (SCI) have stimulated the recent emergence of several therapeutic strategies that are …

Activity-dependent plasticity: implications for recovery after spinal cord injury

SA Dunlop - Trends in Neurosciences, 2008 - cell.com
Spinal cord injury causes devastating loss of function and progressive, potentially life-
threatening, secondary complications. Although significant preclinical advances continue to …

[HTML][HTML] Current status of experimental cell replacement approaches to spinal cord injury

E Eftekharpour, S Karimi-Abdolrezaee… - Neurosurgical focus, 2008 - thejns.org
✓ Despite advances in medical and surgical care, the current clinical therapies for spinal
cord injury (SCI) are largely ineffective. During the last 2 decades, the search for new …

Undesired effects of a combinatorial treatment for spinal cord injury–transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus

F Bretzner, J Liu, E Currie, AJ Roskams… - European Journal of …, 2008 - Wiley Online Library
Transplantations of olfactory ensheathing cells (OECs) have been reported to promote
axonal regeneration and functional recovery after spinal cord injury, but have demonstrated …

Xenografts of expanded primate olfactory ensheathing glia support transient behavioral recovery that is independent of serotonergic or corticospinal axonal …

JD Guest, L Herrera, I Margitich, M Oliveria… - Experimental …, 2008 - Elsevier
Transplantation of olfactory ensheathing glial cells (OEG) may improve the outcome from
spinal cord injury. Proof-of-principle studies in primates are desirable and the feasibility and …

[PDF][PDF] Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury.

C Radtke, M Sasaki, KL Lankford… - Journal of …, 2008 - researchgate.net
Contusive spinal cord injury (SCI) results in a complex lesion that includes cellular and
axonal loss, microglia and macrophage activation, and demyelination. These changes result …