Trypanosomes and leishmania, the causative agents of several tropical diseases, possess a
unique redox metabolism which is based on trypanothione. The bis (glutathionyl) …

Understanding regulatory mechanisms of protein synthesis in eukaryotes is essential for the
accurate annotation of genome sequences. Kozak reported that the nucleotide sequence …

Background Glutamate gated postsynaptic receptors in the central nervous system (CNS)
are essential for environmentally stimulated behaviours including learning and memory in …

The flagellum is attached along the length of the cell body in the protozoan parasite
Trypanosoma brucei and is a defining morphological feature of this parasite. The flagellum …

The protistan phylum Apicomplexa contains many important pathogens and is the subject of
intense genome sequencing efforts. Based upon the genome sequences from seven …

Background Different proteins are required in widely different quantities to build a living cell.
In most organisms, transcription control makes a major contribution to differential …

Nucleotide biosynthesis pathways have been reported to be essential in some protozoan
pathogens. Hence, we evaluated the essentiality of one enzyme in the pyrimidine …

Background Translation of the genome sequence of Plasmodium sp. into biologically
relevant information relies on high through-put genomics technology which includes …

Proteins with tandem repeat (TR) domains have been found in various protozoan parasites,
often acting as targets of B-cell responses. However, the extent of the repeats within …

We have identified five α-tubulin and six β-tubulin isotypes that are expressed in adult
Fasciola hepatica. Amino acid sequence identities ranged between 72 and 95% for fluke α …