The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and …

Endocytic dysfunction is an early pathological change in Alzheimer's disease (AD) and
Down's syndrome (DS). Using primary fibroblasts from DS individuals, we explored the …

Abstract Recessive Charcot-Marie-Tooth disease type-4J (CMT4J) and its animal model, the
pale tremor mouse (plt), are caused by mutations of the FIG4 gene encoding a PI (3, 5) P2 5 …

The biological function of receptors is determined by their appropriate trafficking through the
endosomal pathway. Following internalization, the transferrin (Tf) receptor quantitatively …

Abstract d‐Serine is an astrocyte‐derived regulator for N‐methyl‐d‐aspartate receptors, but
the intracellular routes of its trafficking are still largely unknown. Here, we combined confocal …

The amyloid beta peptide (Aβ) is a central player in Alzheimer's disease (AD) pathology. Aβ
liberation depends on APP cleavage by β-and γ-secretases. The low density lipoprotein …

The term 'tethering factor'has been coined for a heterogeneous group of proteins that all are
required for protein trafficking prior to vesicle docking and SNARE-mediated membrane …

Gap junctions are conglomerations of intercellular channels that are composed of a family of
related but distinct proteins called connexin (Cx) s. It is as yet unknown how the assembly of …

Endocytosed proteins are either returned to the cell surface via a recycling pathway or are
delivered to the lysosome/vacuole to be degraded. Endosomal sorting of the …

Abstract p38 mitogen-activated protein kinases (MAPKs) control the endocytic trafficking of
various growth-related cell surface receptors and transporters. Herein, I demonstrate that …