Polyunsaturated fatty acids (PUFAs) can be classified in n− 3 fatty acids and n− 6 fatty acids,
and in westernized diet the predominant dietary PUFAs are n− 6 fatty acids. Both types of …

7–9). Whereas Ahr J/J mice have no functional AHR, and therefore, all downstream genes
regulated by the AHR should be affected, Cyp1a1/1a2/1b1 J/J mice have a functional AHR …

During inflammation, a large amount of arachidonic acid (AA) is released into the cellular
milieu and cyclooxygenase enzymes convert this AA to prostaglandins that in turn sensitize …

Epoxyeicosatrienoic acids (EETs) reduce infarction of the myocardium after ischemia-
reperfusion injury to rodent and dog hearts mainly by opening sarcolemmal and …

Background and Purpose—Cytochrome P450 epoxygenase metabolizes arachidonic acid
to epoxyeicosatrienoic acids (EETs). EETs are produced in the brain and perform important …

To determine whether sEH inhibitors influence atherosclerotic lesion formation, we used an
established murine model of accelerated atherogenesis, ApoE knockout (-/-) mice. The sEH …

To understand the molecular mechanisms underlying 14, 15-epoxyeicosatrienoic acid (14,
15-EET)–induced angiogenesis, here we have studied the role of signal transducer and …

Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid,
which function in the brain to regulate cerebral blood flow and protect against ischemic brain …

Overexpression of COX2 appears to be both a marker and an effector of neural damage
after a variety of acquired brain injuries, and in natural or pathological aging of the brain …

The aim of the present study was to investigate the anti-inflammatory effects of 14, 15-
epoxyeicosatrienoic acid (EET) on reactivity and Ca2+ sensitivity in TNF-α–stimulated …