Expression profiling of Galectin-3-depleted melanoma cells reveals its major role in melanoma cell plasticity and vasculogenic mimicry

AA Mourad-Zeidan, VO Melnikova, H Wang… - The American journal of …, 2008 - Elsevier
Galectin-3 (Gal-3) is a β-galactoside-binding protein that is involved in cancer progression
and metastasis. Using a progressive human melanoma tissue microarray, we previously …

A role for galectin‐3 in renal tissue damage triggered by ischemia and reperfusion injury

AP Fernandes Bertocchi, G Campanhole… - Transplant …, 2008 - Wiley Online Library
Ischemic‐reperfusion injury (IRI) triggers an inflammatory response involving neutrophils/
macrophages, lymphocytes and endothelial cells. Galectin‐3 is a multi‐functional lectin with …

[HTML][HTML] Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation

J Saegusa, DK Hsu, W Liu, I Kuwabara… - Journal of investigative …, 2008 - Elsevier
Keratinocytes undergo apoptosis in a variety of physiological and pathological conditions.
Galectin-3 is a member of a family of β-galactoside-binding animal lectins expressed …

Nonalcoholic steatohepatitis and hepatocellular carcinoma in galectin‐3 knockout mice

Y Nakanishi, K Tsuneyama, K Nomoto… - Hepatology …, 2008 - Wiley Online Library
Aim: Nonalcoholic fatty liver disease (NAFLD) represents a growing health concern due to
its rapidly increasing prevalence worldwide. Nonalcoholic steatohepatitis (NASH) is a …

Apoptosis induced by oxidized lipids is associated with up-regulation of p66Shc in intestinal Caco-2 cells: protective effects of phenolic compounds

C Giovannini, B Scazzocchio, P Matarrese… - The Journal of …, 2008 - Elsevier
In this study, we investigated the alterations of the redox balance induced by the lipid
fraction of oxLDL in Caco-2 intestinal cells, and the effects of tyrosol and protocatechuic …

Intracellular localisation of galectin-3 has a protective role in chondrocyte survival

C Boileau, F Poirier, JP Pelletier… - Annals of the …, 2008 - ard.bmj.com
Objective: Although galectin-3 (gal-3) is expressed during arthritic disorders, the part it plays
has never been described. The aim of the study was to determine the intracellular roles of …

Regulation of galectin-3 function in mucosal fibroblasts: potential role in mucosal inflammation

E Lippert, M Gunckel, J Brenmoehl… - Clinical & …, 2008 - academic.oup.com
Recently we identified galectin-3 (gal-3), which is secreted by colonic epithelial cells (CEC),
to be a strong activator of colonic lamina propria fibroblasts (CLPF). Modulation of CLPF …

Decreased expression of galectin-3 is associated with metastatic potential of liver fluke-associated cholangiocarcinoma

M Junking, C Wongkham, B Sripa… - European journal of …, 2008 - Elsevier
Galectin-3, a β-galactoside-binding lectin, is a multifunctional protein implicated in a variety
of biological functions, including tumour cell adhesion, proliferation, differentiation, cancer …

Identification of mitochondrial F1F0‐ATP synthase interacting with galectin‐3 in colon cancer cells

DW Kim, KH Kim, BC Yoo, SH Hong, YC Lim… - Cancer …, 2008 - Wiley Online Library
To evaluate the effect of galectin‐3 in cell cycle regulation of colon cancer cells, we looked
for binding molecules interacting with galectin‐3 and examined the changes in cell cycle by …

Rosiglitazone attenuates allergic inflammation and inhibits expression of galectin-3 in a mouse model of allergic rhinitis

JL Han, RY Ding, L Zhao, Z Ren… - Journal of International …, 2008 - journals.sagepub.com
Peroxisome proliferator activated receptor gamma (PPAR-γ) agonists are involved in the
regulation of inflammatory responses and recent studies suggest that PPAR-γ ligands may …