The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Over the past century, understanding the mechanisms underlying muscle fatigue and
weakness has been the focus of much investigation. However, the dominant theory in the …

During exercise, defects in calcium (Ca2+) release have been proposed to impair muscle
function. Here, we show that during exercise in mice and humans, the major Ca2+ release …

Aims Cardiac myopathies are the second leading cause of death in patients with Duchenne
and Becker muscular dystrophy, the two most common and severe forms of a disabling …

In aged skeletal muscle, changes to the composition and function of the contractile
machinery cannot fully explain the observed decrease in the specific force produced by the …

A comprehensive understanding of excitation–contraction (E–C) coupling in skeletal and
cardiac muscle requires that all the major components of the Ca2+ release machinery be …

Ca2+ sparks, localized elevations in cytosolic [Ca2+], are rarely detected in intact adult
mammalian skeletal muscle under physiological conditions. However, they have been …

Ca2+ sparks are the fundamental units that comprise Ca2+-induced Ca2+ release (CICR) in
striated muscle cells. In cardiac muscle, spontaneous Ca2+ sparks underlie the rhythmic …

Background In dystrophic mdx skeletal muscle, aberrant Ca2+ homeostasis and fibre
degeneration are found. The absence of dystrophin in models of Duchenne muscular …

Duchenne muscular dystrophy (DMD) is a lethal X-linked disease caused by the absence of
functional dystrophin. Abnormal excitation-contraction (EC) coupling has been reported in …