Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule
located at junctions between endothelial cells. In analogy of the role of E-cadherin as major …

Aims Hazardous environmental and genetic factors can damage endothelial cells to induce
atherosclerotic vascular disease. Recent studies suggest that class III deacetylase SIRT1 …

To define the roles of endothelial-intrinsic nuclear factor κB (NF-κB) activity in host defense
and multiple organ injury in response to sepsis, we generated double transgenic (TG) mice …

Activation of the Rho GTPase Cdc42 has been shown in endothelial cell monolayers to
prevent disassembly of interendothelial junctions and the increase in endothelial …

We have generated genetically engineered mice that are uniquely susceptible to
lipopolysaccharide (LPS)-induced and mechanical ventilation–induced lung injury in a sex …

Utilizing both the TET-OFF and TET-ON systems in combination with transcriptional control
elements of the Tie-2 gene, we have established a series of transgenic activator and …

Clinical gene-therapy approaches in cardiology have not fulfilled their promise in
randomized, controlled trials, so far, despite striking effects in preclinical models. Lack of …

In the context of the vascular system, cell-cell adhesion is of paramount importance, as
demonstrated by the fact that the inhibition of this process during embryogenesis is usually …

Cardiac allograft arteriosclerosis (CAA) is the leading cause of death in cardiac
transplantation recipients. Nitric oxide (NO) produced by NO donors or nitric oxide synthase …

All the Ang's are characterized structurally by an N-terminal super clustering domain (SCD)
followed by a coiled-coil domain (CCD) and a C-terminal fibrinogen-like domain (FLD)(Ward …