γH2AX and cancer
WM Bonner, CE Redon, JS Dickey… - Nature Reviews …, 2008 - nature.com
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
A Kinner, W Wu, C Staudt, G Iliakis - Nucleic acids research, 2008 - academic.oup.com
DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …
consequences for cell survival and the maintenance of genomic stability. In higher …
DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing
CE Rübe, S Grudzenski, M Kühne, X Dong… - Clinical Cancer …, 2008 - AACR
Purpose: Radiotherapy is an effective cancer treatment, but a few patients suffer severe
radiation toxicities in neighboring normal tissues. There is increasing evidence that the …
radiation toxicities in neighboring normal tissues. There is increasing evidence that the …
Accumulation of DSBs in γ-H2AX domains fuel chromosomal aberrations
H Scherthan, L Hieber, H Braselmann… - Biochemical and …, 2008 - Elsevier
DNA double strand breaks (DSBs) pose a severe hazard to the genome as erroneous
rejoining of DSBs can lead to mutation and cancer. Here, we have investigated the …
rejoining of DSBs can lead to mutation and cancer. Here, we have investigated the …
In vitro studies for the introduction of {gamma}-H2AX foci as an indicator of radiation damage in peripheral blood lymphocytes
T Mandina, O Garcia, S Roch-Lefevre, P Voisin… - 2008 - osti.gov
Biological indicators are used for assessing DNA damage and repair in cells exposed to
ionising radiation. DNA Double-strand breaks (DSBs) have been known as one of the most …
ionising radiation. DNA Double-strand breaks (DSBs) have been known as one of the most …