Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week, placebo-controlled …

HY Meltzer, WV Bobo, IF Nuamah, R Lane… - Journal of Clinical …, 2008 - psychiatrist.com
Objective: To evaluate the efficacy and safety of an extended-release (ER) formulation of
paliperidone in patients with an acute episode of schizophrenia, in the dosage range of 3 to …

[PDF][PDF] Cytochrome P450 enzymes

EG Hrycay, SM Bandiera - Preclinical development handbook: ADME …, 2008 - academia.edu
Cytochrome P450 enzymes Page 645 627 18 CYTOCHROME P450 ENZYMES Eugene G.
Hrycay and Stelvio M. Bandiera University of British Columbia, Vancouver, British Columbia …

Pharmacogenetic Testing of Cyp2D6 in Patients with Aripiprazole-Related Extrapyramidal Symptoms: A Case–Control Study

AA Subuh Surja, KK Reynolds, MW Linder… - Personalized …, 2008 - Taylor & Francis
Aripiprazole is primarily metabolized by the polymorphic CYP2D6. We genotyped four
children (aged 6–15 years) who had developed extrapyramidal symptoms within 1 week of …

Sites of Extra Hepatic Metabolism, Part IV: Brain

Y Wang, JC Bell, HW Strobel - Handbook of Drug Metabolism, 2008 - api.taylorfrancis.com
Drug metabolism in brain tissue has been the subject of several reviews over the recentpast
emphasizing differing aspects of the topic including Phase I and Phase II metabolism …

Molecular genetic mechanisms of schizophrenia and pharmacogenetic characterizations

O Albayram - 2008 - search.proquest.com
Single nucleotide polymorphisms (SNPs) might be at the basis of both the relationship
between genetic diversification influencing drug metabolism (pharmacokinetic approach) or …