Cannabis sativa is the source of a unique set of compounds known collectively as plant
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …

In the last 25 years data has grown exponentially dealing with the discovery of the
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …

Cannabinoids suppress behavioural responses to noxious stimulation and suppress
nociceptive transmission through activation of CB1 and CB2 receptor subtypes. CB1 …

Recently, it has been recognized that the cannabinoid receptor CB2 may play a functionally
relevant role in the central nervous system (CNS). This role is mediated primarily through …

The heterotrimeric G-protein-coupled receptors (GPCR) represent the largest and most
diverse family of cell surface receptors and proteins. GPCR are widely distributed in the …

Though many studies have examined the role of CB2 receptors in immune cell migration, it
has been difficult to form definitive conclusions about the physiopathological role of these …

Although the endocannabinoid anandamide is frequently described to act predominantly in
the cardiovascular system, the molecular mechanisms of its signaling remained unclear. In …

The identification of two biologically active fatty acid amides, N-arachidonoylethanolamine
(anandamide) and oleamide, has generated a great deal of excitement and stimulated …

Background and purpose: Selective cannabinoid CB2 receptor agonists have demonstrated
analgesic activity across multiple preclinical pain models. AM1241 is an indole derivative …

Two subtypes of the mammalian cannabinoid receptor have been identified and
successfully cloned since 1990. The CB1 receptor is primarily located in the central nervous …