Intracranial aneurysms (IAs) are the dilatations of blood vessels in the brain and pose
potential risk of rupture leading to subarachnoid hemorrhage. Although the genetic basis of …

Little is known about the pathology and pathogenesis of the rupture of intracranial
aneurysms. For a better understanding of the molecular processes involved in intracranial …

Purpose: Two polymorphisms in the promoter region of human MMP-1 gene, an insertion of
a guanine at position-1607 and A-519G substitution, have been shown to increase the …

Abstract Background: Matrix metalloproteinase-9 (MMP-9) is involved in the degradation of
the extracellular matrix during physiological and pathological processes. Two functional …

There is evidence suggesting that inflammation plays an important role in the pathogenesis
of intracranial aneurysms (IAs). Interleukin-6 (IL-6) is an important pro-inflammatory cytokine …

Background Among other matrix metalloproteinases (MMPs), gelatinase B (MMP‐9) is
discussed to be associated with the pathogenesis of vascular diseases. Two single …

BACKGROUND: Endoglin is a component of the transforming growth factor-β receptor
complex and is predominantly expressed on the cell surface of endothelial cells. It plays an …

To investigate the association between functional promoter polymorphisms of matrix
metalloproteinase–9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP …

Introduction: Matrix metalloproteinases (MMPs) are involved in connective tissue remodeling
processes associated with chronic liver disease and complications after orthotopic liver …

Publisher Summary Stroke is a complex genetic trait, rather than a simple monogenic
disorder. This chapter introduces the approaches to current stroke genetic research. In …