Initially, gene therapy was viewed as an approach for treating hereditary diseases, but its
potential role in the treatment of acquired diseases such as cancer is now widely …

The number one cause of mortality in the US is cardiovascular related disease. Future
predictions do not see a reduction in this rate especially with the continued rise in obesity [P …

We have demonstrated the ability to deliver and express genes specifically in β-cells for at
least 6 months, using a murine insulin promoter (mIP) in a double-stranded, self …

Background. The authors' previous study has shown that liposome-mediated ex vivo
intracoronary interleukin (IL)-4 and IL-10 combined gene therapy suppressed the allo …

ABSTRACT Type 1 diabetes (T1D) is caused by the autoimmune-mediated destruction of
insulin-producing β cells in the pancreas. T1D affects as many as 3 million patients in the …

≈ 摘要目的探讨黄芪多糖≥ 对非肥胖糖尿病⁄ 小鼠胰岛白细胞介素2 2! 干扰素Χ ƒ 2Χ
表达的影响∀ 方法只⁄ 小鼠随机分为≥ 组和对照组各只∀≥ 组小鼠予≥ 口服个月对照组小鼠予 …

为了研究猪IFN-γ 和IL-4 对疫苗的免疫佐剂效应, 用pcDNA3. 1/IFN-γ 和pcDNA3. 1/IL-4
的重组质粒与口蹄疫双价疫苗配伍免疫小鼠, 检测小鼠抗口蹄疫抗体水平和CD4+/CD8+ T …

Autoimmune diabetes is predominated by a T helper 1 (Th1) response at the expense of an
impaired Th2 response. Although T cells producing Th2 cytokines are generally thought to …

Pancreatic islet transplantation can provide insulin independence to diabetic patients.
However, apoptosis of islets often leads to early graft failure. Genetic engineering with …