In the lungs, parenchymal and vascular remodelling share pathomechanisms that may
explain the relatively high prevalence (30–40%) of pulmonary hypertension (PH) in …

Cyclophosphamide (CTX) is an alkylating cytotoxic drug that primarily affects proliferating
lymphocytes. CTX has been extensively used as a chemotherapeutic and disease-modifying …

Rationale: In interstitial lung disease complicating systemic sclerosis (SSc-ILD), the optimal
prognostic use of baseline pulmonary function tests (PFTs) and high-resolution computed …

1. INTRODUCTION 1.1 An overview of the ILD guideline Since the publication of the first
BTS guidelines for diffuse lung disease nearly 10years ago, 1 the specialty has seen …

Background Lung disease has become the leading cause of mortality and morbidity in
scleroderma (SSc) patients. The frequency, nature, and progression of interstitial lung …

Mice subcutaneously injected with bleomycin, in an experimental model of human systemic
sclerosis, develop cutaneous and lung fibrosis with autoantibody production. CD19 is a …

In this article we study a joint model for longitudinal measurements and competing risks
survival data. Our joint model provides a flexible approach to handle possible nonignorable …

Objective: Systemic sclerosis (SSc) is a generalised autoimmune disease, causing morbidity
and a reduced life expectancy, especially in patients with rapidly progressive diffuse …

Systemic sclerosis (systemic scleroderma) is a chronic connective tissue disease of
unknown etiology that causes widespread microvascular damage and excessive deposition …

Objective. The aim was to compare skin assessment by palpation and by high-frequency
ultrasound in patients with SSc with disease duration< 2 yrs. Methods. Skin thickness and …