The transcription factor NF-κB has served as a standard for inducible transcription factors for
more than 20 years. The numerous stimuli that activate NF-κB, and the large number of …

Research on the biological function of nuclear factor-κB (NF-κB), a key mediator of inducible
transcription in the immune system, has traditionally focused on its role in the initiation of …

The adaptor and signaling proteins TRAF2, TRAF3, cIAP1 and cIAP2 may inhibit alternative
nuclear factor-κB (NF-κB) signaling in resting cells by targeting NF-κB–inducing kinase (NIK) …

NF-κB (nuclear factor-κB) transcription factors have multiple critical roles in the regulation of
immune responses. In unstimulated cells, NF-κB proteins are sequestered in the cytoplasm …

During progression of an in situ to an invasive cancer, epithelial cells lose expression of
proteins that promote cell–cell contact, and acquire mesenchymal markers, which promote …

The NF-κB signaling pathway has particular relevance to several liver diseases including
hepatitis (liver infection by Helicobacter, viral hepatitis induced by HBV and HCV), liver …

Secondary lymphoid organs develop during embryogenesis or in the first few weeks after
birth according to a highly coordinated series of interactions between newly emerging …

Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell …

Nuclear factor-κB (NF-κB) is an inducible transcription factor controlled by two principal
signaling cascades, each activated by a set of signal ligands: the classical/canonical NF-κB …

Here we describe a novel role for the phosphatidylinositol 3-kinase/AKT pathway in
mediating induction of interleukin-6 (IL-6) in response to IL-1. Pharmacological inhibition of …