The motivation to seek cocaine comes in part from a dysregulation of reward processing
manifested in dysphoria, or affective withdrawal. Learning is a critical aspect of drug abuse; …

Background: Adolescent rats are less sensitive to the sedative effects of ethanol than older
animals. They also seem to perceive the reinforcing properties of ethanol. However, unlike …

Marijuana consumption during adolescence has been proposed to be a stepping-stone for
adult cocaine addiction. However, experimental evidence for this hypothesis is missing. In …

Rationale To date, there is no medication specifically approved for cocaine addiction.
Agonist medications are used clinically in the treatment of other addictions, which suggests …

If neurotransmitter balance is upset in the developing nervous system by exposure to
antidepressant drugs, structural and functional hedonic phenotypes of offspring may be …

Rats allowed extended daily access (6 h) to cocaine, consume high doses of the drug and
escalate their cocaine intake over days, resembling the pattern of cocaine use seen in …

Although addiction is a uniquely human phenomenon, some of its pathognomonic features
can be modeled at the animal level. Such features include the euphoric “high” produced by …

The aim of this paper is to present a mathematical dynamic modelling of the effect a
stimulant drug has on different people which, at the same time, can be a useful tool for future …

Neurotrophic factor signaling modulates cellular and behavioral responses to drugs of
abuse. Among other biochemical adaptations, chronic exposure to abused drugs decreases …

Acquisition of drug-reinforced behavior is accompanied by a systematic increase of release
of the neurotransmitter acetylcholine (ACh) rather than dopamine, the expected prime …