Faecal microflora and β-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats
Objectives: Chemotherapy-induced diarrhea (CID) is a well recognized side effect of cancer
treatment. However, the pathophysiology behind this debilitating side effect remains unclear …
treatment. However, the pathophysiology behind this debilitating side effect remains unclear …
Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis
Purpose The pathobiology of alimentary tract (AT) mucositis is complex and there is limited
information about the events which lead to the mucosal damage that occurs during cancer …
information about the events which lead to the mucosal damage that occurs during cancer …
Emerging drugs for chemotherapy-induced mucositis
Background: Chemotherapy-induced mucositis is an increasingly recognized problem in
cancer management, preventing full doses of treatment being given, compromising cure …
cancer management, preventing full doses of treatment being given, compromising cure …
Role of cytokines (TNF-α, IL-1β and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide
Abstract Introduction Irinotecan (CPT-11) is an inhibitor of DNA topoisomerase I and is
clinically effective against several cancers. A major toxic effect of CPT-11 is delayed …
clinically effective against several cancers. A major toxic effect of CPT-11 is delayed …
α-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis
DA Oble, M Mino-Kenudson, J Goldsmith… - The American journal …, 2008 - journals.lww.com
Monoclonal antibodies (mAbs) against the cytotoxic T lymphocyte antigen-4 (CTLA-4)
molecule are used as an adjuvant to experimental tumor immunization protocols in the …
molecule are used as an adjuvant to experimental tumor immunization protocols in the …
Constipation in cancer patients on morphine
J Droney, J Ross, S Gretton, K Welsh, H Sato… - Supportive care in …, 2008 - Springer
Goals of work Constipation is a significant problem in patients taking morphine for cancer
pain. The aims of this study were (1) to assess the magnitude of constipation in this study …
pain. The aims of this study were (1) to assess the magnitude of constipation in this study …
Technological advances in mucositis research: new insights and new issues
The last decade has seen a significant acceleration in the introduction of molecular tools
used in cancer diagnosis and treatment. Driving factors have been the movement of …
used in cancer diagnosis and treatment. Driving factors have been the movement of …
Measuring tools for gastrointestinal toxicity
RN Butler - Current Opinion in Supportive and Palliative Care, 2008 - journals.lww.com
In the past 12 months the 13 C sucrose breath test has been applied to a series of animal
models of chemotherapeutic damage, showing rapid monitoring of the efficacy of particular …
models of chemotherapeutic damage, showing rapid monitoring of the efficacy of particular …
[PDF][PDF] Medication induced constipation and diarrhea
RC Toney, D Wallace, S Sekhon… - Practical …, 2008 - ficomputing.net
Constipation and diarrhea as a side effect of medica-tions is a frequent occurrence.
Constipation is the most common gastrointestinal complaint that leads to physician visits …
Constipation is the most common gastrointestinal complaint that leads to physician visits …
The nature of small intestinal mucositis: a video-capsule endoscopy study
K Triantafyllou, J Dervenoulas, P Tsirigotis… - Supportive Care in …, 2008 - Springer
Background and aims Alimentary mucositis is a life-threatening side effect in patients
receiving conditioning therapy for stem cell transplantation. While oral mucosa can be easily …
receiving conditioning therapy for stem cell transplantation. While oral mucosa can be easily …