Targeting of tetraspanin proteins—potential benefits and strategies

ME Hemler - Nature reviews Drug discovery, 2008 - nature.com
The tetraspanin transmembrane proteins have emerged as key players in malignancy, the
immune system, during fertilization and infectious disease processes. Tetraspanins engage …

Cellular proteins in influenza virus particles

ML Shaw, KL Stone, CM Colangelo, EE Gulcicek… - PLoS …, 2008 - journals.plos.org
Virions are thought to contain all the essential proteins that govern virus egress from the host
cell and initiation of replication in the target cell. It has been known for some time that …

Clathrin-and caveolin-independent entry of human papillomavirus type 16—involvement of tetraspanin-enriched microdomains (TEMs)

G Spoden, K Freitag, M Husmann, K Boller, M Sapp… - PloS one, 2008 - journals.plos.org
Background Infectious entry of human papillomaviruses into their host cells is an important
step in the viral life cycle. For cell binding these viruses use proteoglycans as initial …

[HTML][HTML] Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms

O Barreiro, M Zamai, M Yanez-Mo, E Tejera… - The Journal of cell …, 2008 - ncbi.nlm.nih.gov
Abstract VCAM-1 and ICAM-1, receptors for leukocyte integrins, are recruited to cell–cell
contact sites on the apical membrane of activated endothelial cells. In this study, we show …

[HTML][HTML] Appearance of new tetraspanin genes during vertebrate evolution

A Garcia-España, PJ Chung, IN Sarkar, E Stiner… - Genomics, 2008 - Elsevier
A detailed phylogenetic analysis of tetraspanins from 10 fully sequenced metazoan
genomes and several fungal and protist genomes gives insight into their evolutionary origins …

Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins

K Sato, J Aoki, N Misawa, E Daikoku, K Sano… - Journal of …, 2008 - Am Soc Microbiol
Accumulating evidence indicates that human immunodeficiency virus type 1 (HIV-1)
acquires various cellular membrane proteins in the lipid bilayer of the viral envelope …

A CD63 mutant inhibits T‐cell tropic human immunodeficiency virus type 1 entry by disrupting CXCR4 trafficking to the plasma membrane

T Yoshida, Y Kawano, K Sato, Y Ando, J Aoki, Y Miura… - Traffic, 2008 - Wiley Online Library
We have discovered that an N‐terminal deletion mutant of a membrane protein,
CD63,(CD63ΔN) blocks entry of CXCR4‐using, T‐cell tropic human immunodeficiency virus …

Identification of host proteins associated with retroviral vector particles by proteomic analysis of highly purified vector preparations

MM Segura, A Garnier, MR Di Falco, G Whissell… - Journal of …, 2008 - Am Soc Microbiol
The Moloney murine leukemia virus (MMLV) belongs to the Retroviridae family of enveloped
viruses, which is known to acquire minute amounts of host cellular proteins both on the …

Monitoring early fusion dynamics of human immunodeficiency virus type 1 at single-molecule resolution

TM Dobrowsky, Y Zhou, SX Sun, RF Siliciano… - Journal of …, 2008 - Am Soc Microbiol
The fusion of human immunodeficiency virus type 1 (HIV-1) to host cells is a dynamic
process governed by the interaction between glycoproteins on the viral envelope and the …

CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophages

E Ruiz-Mateos, A Pelchen-Matthews… - Journal of …, 2008 - Am Soc Microbiol
During the assembly of human immunodeficiency virus type 1 (HIV-1) particles, the
tetraspanin CD63 can be incorporated into the viral membrane. Indeed, cell surface …