A number of observations have shown that mitochondria are at the center of the
pathophysiology of the failing heart and mitochondrial-based oxidative stress (OS) …

Abstract Analysis of mitochondrial function is central to the study of intracellular energy
metabolism, mechanisms of cell death and pathophysiology of a variety of human diseases …

The assembly of sarcomeric proteins into the highly organized structure of the sarcomere is
an ordered and complex process involving an array of structural and associated proteins …

The protozoan phylum Apicomplexa encompasses∼ 5000 species of obligate intracellular
parasites, including those responsible for malaria and toxoplasmosis. Rather than dividing …

Dysfunction of plectin, a 500-kD cytolinker protein, leads to skin blistering and muscular
dystrophy. Using conditional gene targeting in mice, we show that plectin deficiency results …

Vimentin is one of the intermediate filaments that functions in structural support, signal
transduction and organelle positioning of a cell. In the present study, we report the …

Intermediate filaments (IF) represent one of three main cytoskeletal structures in most animal
cells. The human IF protein family includes about 70 members divided into five main groups …

We explored the involvement of the muscle-specific intermediate filament protein desmin in
the model of tumor necrosis factor α (TNF-α)–induced cardiomyopathy. We demonstrate that …

Local control of ATP/ADP ratio is essential for efficient functioning of cellular ATPases. Since
creatine kinase (CK) activity and mitochondrial content are reduced in heart failure (HF), and …

Desmin mutations underlie inherited myopathies/cardiomyopathies with varying severity and
involvement of the skeletal and cardiac muscles. We developed a transgenic mouse model …