Cyclooxygenase (COX) is the key enzyme in the conversion of arachidonic acid to
prostanoids, lipid mediators involved in several physiological and pathological processes …

Diabetic peripheral neuropathy (DPN) is the most common diabetic complication and is the
leading cause of diabetes-related hospital admissions and non-traumatic amputations. DPN …

Cyclooxygenase‐derived prostaglandins modulate cardiovascular disease risk. We
genotyped 2212 Atherosclerosis Risk in Communities study participants (1,023 incident …

Background One of the more influential criminological theories advanced in recent years is
Moffitt's developmental taxonomy. A line of research has tested the core propositions from …

BACKGROUND: A hallmark feature of atherosclerosis is inflammation mediated by
prostaglandins (PGs) catalyzed by the enzyme cyclooxygenase (COX). The present study …

Myocardial infarction (MI) is an important clinical problem because of its large contribution to
mortality. The main causal and treatable risk factors for MI include hypertension …

Platelets play a key role in thrombosis and haemostasis, which can be either beneficial or
deleterious depending on the circumstance. Antiplatelet therapy is the 'cornerstone'in the …

Prostaglandins (PGs) and their specific receptors play critical roles in atherothrombosis.
Produced from arachidonic acid via two cyclooxygenase (COX) isoforms, PGs mediate their …

Abstract Aim: Prostaglandin E2 (PGE2) is considered to be an important mediator of tissue
destruction in periodontitis. The cyclooxygenase (COX) catalyses the production of PGs …

COX-2 overexpression is known to be an important mechanism in gastric carcinogenesis.
Previously we have found that early-onset gastric cancer has a unique COX-2 low …