The most frequent subtype of autosomal dominant inherited spinocerebellar ataxias is
caused by CAG repeat expansions of more than 55 units in the ataxin-3 gene. The clinical …

Memory loss is the signature feature of Alzheimer's disease, and therapies that prevent or
delay its onset are urgently needed. Effective preventive strategies likely offer the greatest …

Aging is characterized by a progressive deterioration of physiological functions and
metabolic processes. Healthy aging remains one of the ideals of modern society. In aging …

Huntington's disease (HD) is associated with transcriptional dysregulation, and multiple
studies with histone deacetylase (HDAC) inhibitors suggest that global approaches for …

The expansion of polyglutamine tracts in a variety of proteins causes devastating,
dominantly inherited neurodegenerative diseases, including six forms of spinal cerebellar …

Abstract Spinocerebellar Ataxia type 1 (SCA1) and Huntington's disease (HD) are two
polyglutamine disorders caused by expansion of a CAG repeat within the coding regions of …

One of the most widely used transgenic animal models in biology is Drosophila
melanogaster, the fruit fly. Chemical information from this exceedingly small organism is …

Huntington's disease (HD) is caused by an extended polyglutamine (polyQ) tract in the
Huntingtin protein. Neuronal and glial dysfunction precedes the neurodegeneration and …

DNA polymerase γ (pol γ) is the sole DNA polymerase devoted to mitochondrial DNA
(mtDNA) replication. We have characterized the molecular and physiological effects of over …

Drosophila is a well-established model to study the molecular basis of neurodegenerative
diseases. We carried out a misexpression screen to identify genes involved in …