HDL-replacement therapy: mechanism of action, types of agents and potential clinical indications

AT Remaley, M Amar, D Sviridov - Expert review of cardiovascular …, 2008 - Taylor & Francis
HDL-replacement therapy is a promising new treatment strategy involving the acute
administration of HDL to rapidly stabilize patients at imminent risk for developing a …

[HTML][HTML] Asymmetry in the lipid affinity of bihelical amphipathic peptides: a structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides

AA Sethi, JA Stonik, F Thomas, SJ Demosky… - Journal of Biological …, 2008 - ASBMB
ApoA-I contains a tandem array of amphipathic helices with varying lipid affinity, which are
critical in its ability to bind and remove lipids from cells by the ABCA1 transporter. In this …

Acute effects of high-density lipoproteins: biochemical basis and clinical findings

G Chiesa, C Parolini, CR Sirtori - Current opinion in cardiology, 2008 - journals.lww.com
Administration of synthetic high-density lipoproteins has proven to be effective in promoting
atherosclerosis regression not only in animal models, but also in humans. Applications to …

A pivotal role of the human kidney in catabolism of HDL protein components apolipoprotein AI and A-IV but not of A-II

JH Graversen, G Castro, A Kandoussi, H Nielsen… - Lipids, 2008 - Springer
Renal handling of major HDL components was studied by analyzing urine from patients with
Fanconi syndrome, a rare renal proximal tubular reabsorption failure, including dysfunction …

The Treatment of Dyslipidemia—What's Left in the Pipeline?

O Rau, H Zettl, L Popescu, D Steinhilber… - ChemMedChem …, 2008 - Wiley Online Library
Dyslipidemia is a pathological alteration of serum lipid levels. The most common forms are
either elevations of triglycerides or low density lipoprotein cholesterol associated with a …

Therapies to increase ApoA-I and HDL-cholesterol levels

WM Brown, FS Chiacchia - Drug Target Insights, 2008 - journals.sagepub.com
Cholesterol is transported around the body in the form of lipoprotein (lipid/protein)
complexes, because it is almost insoluble in water. High-density lipoprotein (HDL) particles …

The editor's roundtable: expanded versus standard lipid panels in assessing and managing cardiovascular risk

D Sulkes, BG Brown, RM Krauss, JP Segrest… - American Journal of …, 2008 - ajconline.org
The Editor’s Roundtable: Expanded Versus Standard Lipid Panels in Assessing and Managing
Cardiovascular Risk - American Journal of Cardiology Skip to Main Content The American …

ApoA‐IMilano from structure to clinical application

I Eberini, E Gianazza, L Calabresi, CR Sirtori - Annals of Medicine, 2008 - Taylor & Francis
Apolipoprotein A‐IMilano (apoA‐IM) is characterized by a Cys for Arg substitution and
formation of homo‐and apoA‐II heterodimers. In the last years, some important insights on …

High-density lipoprotein and atheroma monitoring

SJ Nicholls, EM Tuzcu - Current Opinion in Cardiology, 2008 - journals.lww.com
High-density lipoprotein and atheroma monitoring : Current Opinion in Cardiology High-density
lipoprotein and atheroma monitoring : Current Opinion in Cardiology Log in or Register …

Letter by Sutton et al Regarding Article,“Effect of Rosuvastatin Therapy on Coronary Artery Stenoses Assessed by Quantitative Coronary Angiography: A Study to …

BS Sutton, RS Blumenthal, NK Kapur - Circulation, 2008 - Am Heart Assoc
The QCA changes seen in the study, though statistically significant, are exceedingly small.
Previous work by Nissen and others has indicated that “plaque progression and regression …