Genomics has revolutionized every aspect of microbiology. Now, 13 years after the first
bacterial genome was sequenced, it is important to pause and consider what has changed …

Vaccine design is progressing from empiricism towards the increasingly rational
presentation of the targets of protective immunity. Nevertheless, most current vaccine …

Genome sequences from many organisms, including humans, have been completed, and
high-throughput analyses have produced burgeoning volumes of 'omics' data …

Chlamydia infections cause substantial morbidity worldwide and effective prevention will
depend on a vaccine. Since Chlamydia immunity is T cell-mediated, a major impediment to …

There is a long history of remarkable success in developing vaccines against bacteria that
are extracellular pathogens. In general, the development of vaccines against intracellular …

Gram‐positive streptococci are non‐motile, chain‐forming bacteria commonly found in the
normal oral and bowel flora of warm‐blooded animals. Over the past decade, a proteomic …

Infectious diseases are the greatest cause of global morbidity and mortality. About half of this
burden is caused by pathogenic bacteria. One of the most effective ways to prevent …

Bacterial infectious diseases remain a major cause of deaths and disabilities in the world.
Although conventional vaccinology approaches were successful in conferring protection …

This article provides an overview of developments in approaches to identify novel bacterial
components for use in recombinant subunit vaccines. In particular it describes the processes …

Desde hace más de 200 años la vacunación ha sido una herramienta muy efectiva en la
prevención de enfermedades infecciosas; sin embargo, los métodos convencionales han …