Background and purpose: Inhibitors of histone deacetylase (HDAC) are emerging as a
promising class of anti‐cancer drugs, but a generic deregulation of transcription in …

The p53 tumor suppressor induces cell growth arrest and apoptosis in response to DNA
damage. Because these functions are achieved largely by the transcriptional properties of …

Deletion of the distal region of chromosome 1 frequently occurs in a variety of human
cancers, including aggressive neuroblastoma. Previously, we have identified a 500-kb …

Prostate cancer has been projected to cause almost 10% of all male cancer deaths in the
United States in 2007. The incidence of mutations in the tumor suppressor genes Rb1 and …

Abstract NEDL1 (NEDD4-like ubiquitin protein ligase-1) is a newly identified HECT-type E3
ubiquitin protein ligase highly expressed in favorable neuroblastomas as compared with …

As Jessani et al. 1 point out development of cell and animal models that accurately depict
human tumorigenesis remains a major goal of cancer research. Clam cancer offers …

In nature, the soft shell clam, Mya arenaria, develops a fatal blood cancer in which a highly
conserved homologue for wild-type human p53 protein is rendered nonfunctional by …

In this study, we employed a panel of cell lines to determine whether p53-dependent cell
death in neuroblastoma (NB) cells is caused by apoptotic cellular function, and we further …

During rat hepatocarcinogenesis preneoplastic lesions (PNL) emerge which may persist
(pPNL) and be sites of progress to cancer or suffer remodeling (rPNL) tending to disappear …

Abstract Defects in Major Histocompatibility class I cell surface expression is thought to allow
escape of tumor cells from immune surveillance. Hitherto, it is unclear whether this …