Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been
suggested that cytokines and other peptides that are produced, expressed, and released by …

Recently, the term" inflammaging" was coined by Franceshci and colleagues to characterize
a widely accepted paradigm that ageing is accompanied by a low-grade chronic up …

Advanced age is associated with defects in all of the cells of the innate immune system,
including numbers, function, and early stages of activation. This review, presents the current …

This review focuses on the emerging evidence that attenuation of the production of reactive
oxygen species and inhibition of inflammatory pathways play a central role in the antiaging …

Age‐dependent bone loss has been well documented in both human and animal models.
Although the underlying causal mechanisms are probably multifactorial, it has been …

In schizophrenia and depression, opposite patterns of type-1-type-2 immune response seem
to be associated with differences in the activation of the enzyme indoleamine 2, 3 …

Immune dysregulation and inflammation play a major role in the pathology of age-related
disorders. In an earlier study, the microarray data from our laboratory indicated an increase …

An epidemic of overweight/obesity and type 2 diabetes, caused by overeating nutrient-poor
energy-dense foods and a sedentary lifestyle, is spreading rapidly throughout the world …

As we age, it is common for certain phenotypic changes to arise within the population. A
number of observations have led scientists to believe that these changes result from an …

Alzheimer disease is the most common cause of dementia, yet its clinical diagnosis remains
uncertain until an eventual postmortem histopathology examination. Currently, therapy for …