Recent advances in the synthesis of purine derivatives and their precursors

M Legraverend - Tetrahedron, 2008 - Elsevier
The purine ring is the most ubiquitous nitrogen-containing heterocycle in nature, 1 since,
besides the numerous purine derivatives found in various marine organisms and plants, it is …

Small molecules ATP-competitive inhibitors of FLT3: a chemical overview

S Schenone, C Brullo, M Botta - Current medicinal chemistry, 2008 - ingentaconnect.com
FLT3 is a tyrosine kinase (TK), member of the class III TK receptor family, normally
expressed in hematopoietic, immune and neural systems, also playing an important role in …

Discovery of selective aminothiazole aurora kinase inhibitors

CB Andersen, Y Wan, JW Chang, B Riggs… - ACS chemical …, 2008 - ACS Publications
Aurora family kinases regulate important events during mitosis including centrosome
maturation and separation, mitotic spindle assembly, and chromosome segregation …

Pharmacophore modelling and virtual screening for identification of new Aurora‐A kinase inhibitors

XQ Deng, HY Wang, YL Zhao, ML Xiang… - Chemical biology & …, 2008 - Wiley Online Library
Aurora‐A has been identified as one of the most attractive targets for cancer therapy and a
considerable number of Aurora‐A inhibitors have been reported recently. In order to clarify …

Molecular docking/dynamics studies of Aurora A kinase inhibitors

TT Talele, ML McLaughlin - Journal of molecular graphics and modelling, 2008 - Elsevier
The binding modes of a known 1, 4, 5, 6-tetrahydropyrrolo [3, 4-c] pyrazole, quinazoline,
pyrimidine and indolinone series of Aurora A kinase inhibitors have been studied using …

An expedient microwave-assisted, solvent-free, solid-supported synthesis of pyrrolo [2, 3-d] pyrimidine-pyrano [5, 6-c] coumarin/[6, 5-c] chromone derivatives by …

E Ramesh, R Raghunathan - Tetrahedron Letters, 2008 - Elsevier
A rapid synthesis of pyrrolo [2, 3-d] pyrimidine annulated pyrano [5, 6-c] coumarin/[6, 5-c]
chromone derivatives has been accomplished in good yields via an intramolecular domino …

Indium chloride catalyzed intramolecular cyclization of N-aryl imines: synthesis of pyrrolo [2, 3-d] pyrimidine annulated tetrahydroquinoline derivatives

E Ramesh, R Raghunathan - Tetrahedron Letters, 2008 - Elsevier
The intramolecular aza Diels–Alder cyclization reaction of aldimines derived from aromatic
amines and N-prenyl/cinnamyl derivatives of pyrrolo [2, 3-d] pyrimidine were efficiently …

An Efficient Synthesis of 2‐Chloropyrimidines via Pd‐catalyzed Regioselective Dechlorination of 2,4‐Dichloropyrimidines in the Presence of NaHCO3

YM Zhang, GU Min, MA Hui, T Jie, LU Wei… - Chinese Journal of …, 2008 - cir.nii.ac.jp
An Efficient Synthesis of 2‐Chloropyrimidines via Pd‐catalyzed Regioselective Dechlorination
of 2,4‐Dichloropyrimidines in the Presence of NaHCO<sub>3</sub> | CiNii Research CiNii 国立 …

Highly efficient palladium-catalyzed hydrostannation of ethyl ethynyl ether

IP Andrews, O Kwon - Tetrahedron letters, 2008 - Elsevier
The palladium-catalyzed hydrostannation of acetylenes is widely exploited in organic
synthesis as a means of forming vinyl stannanes for use in palladium-catalyzed cross …